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Journal article

Recognition of the E-C4 element from the C4 complement gene promoter by the upstream stimulatory factor-1 transcription factor.

Abstract:

Activation of complement gene expression plays a major role in the response to antigenic challenge. The induction of complement synthesis occurs primarily in liver and in macrophages and is mediated, at least in part, by increased transcription of the complement genes. For example, transcription of the C4 complement gene, which plays a crucial role in the complement pathway, is induced in response to acute inflammation or tissue injury. Previous work has defined the elements present in the C4...

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Publication status:
Published

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Journal:
Journal of Immunology More from this journal
Volume:
159
Issue:
12
Pages:
6176-6183
Publication date:
1997-12-01
EISSN:
1550-6606
ISSN:
0022-1767

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