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Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease.

Abstract:

CONTEXT: Recently six DNA variants, two of which (M55V and 001Msp) are present in nuclear factor-kappaB inhibitors SUMO-4 and MAP3K7IP2 and four of which (fcrl3_3, fcrl3_4, fcrl3_5, and fcrl3_6) modulate nuclear factor-kappaB binding and production of the B cell surface molecule FCRL3, have been reported to be associated with a number of autoimmune diseases. OBJECTIVE: The aim of this study was to investigate the association of these polymorphisms with disease in a large UK Caucasian Graves'...

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Publisher copy:
10.1210/jc.2005-1634

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Heward, JM More by this author
Carr-Smith, J More by this author
Franklyn, JA More by this author
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Journal:
The Journal of clinical endocrinology and metabolism
Volume:
91
Issue:
3
Pages:
1056-1061
Publication date:
2006-03-05
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
URN:
uuid:0b4c11cb-3bd9-44a7-96ba-9323bf1ab53a
Source identifiers:
176328
Local pid:
pubs:176328

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