Cyclin D and cyclin E expression in normal and adenomatous pituitary.

Journal article

OBJECTIVES: Cyclins play an important role in the regulation of cell progression through the cell cycle. Over-expression of the cyclins has been shown in many different tumour types. Pituitary adenomas are a common form of endocrine neoplasia in the human, but have been little studied in terms of the expression of the principal cyclins regulating checkpoint exit, cyclin D1 and cyclin E. METHODS: We therefore investigated the expression of cyclin D1 and cyclin E in a range of benign and metast...

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Authors: Jordan, S; Lidhar, K; Korbonits, M; Lowe, D; Grossman, AB

• Publication status: Published
• Journal: European journal of endocrinology / European Federation of Endocrine Societies
• Volume: 143
• Issue: 1
• Pages: R1-R6
• Publication date: 2000-07-01
• DOI: 10.1530/eje.0.143r001
• EISSN: 1479-683X
• ISSN: 0804-4643
• Language: English
• Keywords: Cell Nucleus; Pregnancy; Humans; Immunohistochemistry; Female; Prolactinoma; Pituitary Gland; Human Growth Hormone; Cyclins; Pituitary Neoplasms; Adenoma; Cyclin E; Cushing Syndrome