Synthesis and structural studies of gallium(III) and indium(III) complexes of 2-acetylpyridine thiosemicarbazones

Journal article

Four 2-acetylpyridine 4N-alkyl thiosemicarbazones, and their Ga(III) and In(III) complexes have been prepared and characterised by fluorescence, UV-Vis, IR, 1H and 13C NMR spectroscopy, mass spectrometry and X-ray crystallographic analysis. Comparison of the crystal structures gave an insight into the nature of the complexes formed, demonstrating a preference for [ML2]+ type complexes with gallium and [MLX3] species with indium. Stability studies on two candidates indicated that complex [InL3Cl2MeOH] was stable to chemical degradation for prolonged periods in human serum, giving this complex potential for further biological evaluation. © 2009 Elsevier B.V. All rights reserved.

Authors: Chan, J; Thompson, A; Jones, M; Peach, J

• Publication status: Published
• Journal: INORGANICA CHIMICA ACTA
• Volume: 363
• Issue: 6
• Pages: 1140-1149
• Publication date: 2010-04-05
• DOI: 10.1016/j.ica.2009.10.020
• ISSN: 0020-1693
• Language: English
• Keywords: Gallium complexes; Crystal structures; Thiosemicarbazones; Fluorescence; Indium complexes