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Production of interleukin-1 and interleukin-6 by human keratinocytes and squamous cell carcinoma cell lines.

Abstract:

Cultured human keratinocytes and squamous cell carcinoma (SCC) cell lines were analyzed for the presence of ribonucleic acid (RNA) transcripts for the cytokines interleukin-1 and interleukin-6 and for these proteins. This study demonstrates that both cytokines are synthesized and secreted by both normal keratinocytes and SCC lines. The rate of secretion of these cytokines can be augmented in response to a variety of stimuli including tumor necrosis factor-alpha, granulocyte-macrophage colony ...

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Publication status:
Published

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Authors


Partridge, M More by this author
Chantry, D More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
The Journal of investigative dermatology
Volume:
96
Issue:
5
Pages:
771-776
Publication date:
1991-05-05
DOI:
EISSN:
1523-1747
ISSN:
0022-202X
URN:
uuid:0b440707-c393-4bc9-9d07-36df5a5d5829
Source identifiers:
481736
Local pid:
pubs:481736

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