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Live Leishmania promastigotes can directly activate primary human natural killer cells to produce interferon-gamma.

Abstract:

Natural killer (NK) cells have been implicated in the natural protection and healing of leishmaniasis by their ability to secrete the macrophage activating cytokine interferon (IFN)gamma. Previous studies have demonstrated that early production of interleukin (IL)-12 triggers IFN gamma secretion by NK cells. Here we report that live Leishmania promastigotes (the form that is injected by the vector) can directly induce human peripheral blood NK cells from healthy donors to IFN gamma secretion ...

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Publication status:
Published

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Journal:
Clinical and experimental immunology More from this journal
Volume:
131
Issue:
3
Pages:
457-467
Publication date:
2003-03-01
DOI:
EISSN:
1365-2249
ISSN:
0009-9104
Language:
English
Keywords:
Pubs id:
pubs:434240
UUID:
uuid:0b3e37c4-9d99-429d-8d2f-e3d3fb657c0a
Local pid:
pubs:434240
Source identifiers:
434240
Deposit date:
2013-11-16

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