Live Leishmania promastigotes can directly activate primary human natural killer cells to produce interferon-gamma.

Journal article

Natural killer (NK) cells have been implicated in the natural protection and healing of leishmaniasis by their ability to secrete the macrophage activating cytokine interferon (IFN)gamma. Previous studies have demonstrated that early production of interleukin (IL)-12 triggers IFN gamma secretion by NK cells. Here we report that live Leishmania promastigotes (the form that is injected by the vector) can directly induce human peripheral blood NK cells from healthy donors to IFN gamma secretion ...

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Authors: Nylén, S; Maasho, K; Söderstrom, K; Ilg, T; Akuffo, H

• Publication status: Published
• Journal: Clinical and experimental immunology
• Volume: 131
• Issue: 3
• Pages: 457-467
• Publication date: 2003-03-01
• DOI: 10.1046/j.1365-2249.2003.02096.x
• EISSN: 1365-2249
• ISSN: 0009-9104
• Language: English
• Keywords: Interleukin-10; Cytotoxicity, Immunologic; CD4-Positive T-Lymphocytes; Animals; Glycosphingolipids; Protozoan Proteins; Immunophenotyping; Killer Cells, Natural; Cell Line; Interferon-gamma; Humans; Antigens, Protozoan; Leishmania; Cell Division