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Viral escape and T cell exhaustion in hepatitis C virus infection analysed using Class I peptide tetramers.

Abstract:

Hepatitis C virus (HCV) has infected over 170 million people world wide, and in the majority sets up a chronic infection associated with hepatic inflammation. How it evades host immunity, particularly CD8+ T cells (CTL) is unclear, but two major factors are likely to operate, viral escape mutation and T cell exhaustion. We have investigated the role of CTL in control of infection during acute disease using Class I peptide tetramers. Although the immune response is quite diverse and numerous e...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Immunology letters More from this journal
Volume:
85
Issue:
2
Pages:
165-171
Publication date:
2003-01-01
Event title:
6th Elsinore Meeting on Infection Immunity
DOI:
EISSN:
1879-0542
ISSN:
0165-2478
Keywords:
Pubs id:
pubs:15456
UUID:
uuid:0b3d6273-fb76-44c9-885d-2e52767cb175
Local pid:
pubs:15456
Source identifiers:
15456
Deposit date:
2012-12-19

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