Viral escape and T cell exhaustion in hepatitis C virus infection analysed using Class I peptide tetramers.

Conference item

Hepatitis C virus (HCV) has infected over 170 million people world wide, and in the majority sets up a chronic infection associated with hepatic inflammation. How it evades host immunity, particularly CD8+ T cells (CTL) is unclear, but two major factors are likely to operate, viral escape mutation and T cell exhaustion. We have investigated the role of CTL in control of infection during acute disease using Class I peptide tetramers. Although the immune response is quite diverse and numerous e...

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Authors: Kantzanou, M; Lucas, M; Barnes, E; Komatsu, H; Dusheiko, G

• Publication status: Published
• Journal: Immunology letters
• Volume: 85
• Issue: 2
• Pages: 165-171
• Publication date: 2003-01-01
• Event title: 6th Elsinore Meeting on Infection Immunity
• DOI: 10.1016/S0165-2478(02)00224-9
• EISSN: 1879-0542
• ISSN: 0165-2478
• Keywords: Hepatitis C; T-Lymphocytes, Cytotoxic; Middle Aged; Polymerase Chain Reaction; Histocompatibility Antigens Class I; Mutation; Male; Female; Viral Nonstructural Proteins; Humans; Peptides