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Macro/nano-structured silicon as solid support for antibody arrays: Surface design, reproducibility, and assay characteristics enabling discovery of kallikrein gene products for prostate disease diagnostics

Abstract:

To facilitate high-throughput biomarker discovery and high-density protein-chip array analyses of complex biological samples, a novel macro- and nanoporous silicon surface for protein microarrays was developed. The surface offers three-dimensional surface enlarging properties and spot confinement, enabling both high sensitivity bioassays and design of high density arrays. Reproducible manufacturing of the protein chip surface was accomplished as demonstrated by the low imprecision when standa...

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Publisher copy:
10.1385/Nano:1:1:93

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
Journal:
Nanobiotechnology More from this journal
Volume:
1
Issue:
1
Pages:
93-103
Publication date:
2005-01-01
DOI:
ISSN:
1551-1286
Language:
English
Keywords:
Pubs id:
pubs:367545
UUID:
uuid:0b3ad8ed-a76f-4b10-9267-5c7eb3cb9323
Local pid:
pubs:367545
Source identifiers:
367545
Deposit date:
2013-11-16

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