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HMGB1 interacts differentially with members of the Rel family of transcription factors.

Abstract:

HMGB1 is an architectural factor that enhances the DNA binding affinity of several proteins. We have investigated the influence of HMGB1 on DNA binding by members of the Rel family. HMGB1 enhances DNA binding by p65/p50 and p50/p50, but reduces binding by p65/p65, c-Rel/c-Rel, p65/c-Rel, and p50/c-Rel. In pull-down assays, HMGB1 interacts directly with the p50 subunit via its HMG boxes and this interaction is weakened by the presence of the acidic tail. Functionally, HMGB1 is required for the...

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Publication status:
Published

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Journal:
Biochemical and biophysical research communications More from this journal
Volume:
302
Issue:
2
Pages:
421-426
Publication date:
2003-03-01
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
Language:
English
Keywords:
Pubs id:
pubs:374159
UUID:
uuid:0b364c68-4fdf-4fc4-92b1-b98388dedaf4
Local pid:
pubs:374159
Source identifiers:
374159
Deposit date:
2013-11-17

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