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A comparison on effects of normalisations in the detection of differentially expressed genes

Abstract:

Background: Various normalisation techniques have been developed in the context of microarray analysis to try to correct expression measurements for experimental bias and random fluctuations. Major techniques include: total intensity normalisation; intensity dependent normalisation; and variance stabilising normalisation. The aim of this paper is to discuss the impact of normalisation techniques for two-channel array technology on the process of identif...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/1471-2105-10-61

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Role:
Author
Publisher:
BioMed Central
Journal:
BMC Bioinformatics More from this journal
Volume:
10
Article number:
61
Publication date:
2009-02-13
Acceptance date:
2009-02-13
DOI:
EISSN:
1471-2105
Language:
English
Keywords:
Pubs id:
pubs:104713
UUID:
uuid:0b357f24-b28c-45cf-8e46-88a71a7b1d8c
Local pid:
pubs:104713
Source identifiers:
104713
Deposit date:
2012-12-19

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