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Ex vivo-expanded human regulatory T cells prevent the rejection of skin allografts in a humanized mouse model.

Abstract:

BACKGROUND: Composite tissue transplantation effectively reconstructs the most complex defects, but its use is limited because of harmful immunosuppression and the high susceptibility of skin to rejection. Development of tolerance is an ideal solution, and protocols using regulatory T cells (Tregs) to achieve this have been promising in experimental animal models. The aim of this study was to investigate the ability of human Tregs to regulate immune responses to a human skin allograft in vivo...

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Publication status:
Published

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Publisher copy:
10.1097/tp.0b013e3181ff8772

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Journal:
Transplantation More from this journal
Volume:
90
Issue:
12
Pages:
1321-1327
Publication date:
2010-12-01
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
Language:
English
Keywords:
Pubs id:
pubs:263472
UUID:
uuid:0b328922-41c9-4f67-bf45-d4fb77c1370d
Local pid:
pubs:263472
Source identifiers:
263472
Deposit date:
2013-11-16

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