Brain responses to chronic social defeat stress: effects on regional oxidative metabolism as a function of a hedonic trait, and gene expression in susceptible and resilient rats.

Journal article

Chronic social defeat stress, a depression model in rats, reduced struggling in the forced swimming test dependent on a hedonic trait-stressed rats with high sucrose intake struggled less. Social defeat reduced brain regional energy metabolism, and this effect was also more pronounced in rats with high sucrose intake. A number of changes in gene expression were identified after social defeat stress, most notably the down-regulation of Gsk3b and Map1b. The majority of differences were between stress-susceptible and resilient rats. Conclusively, correlates of inter-individual differences in stress resilience can be identified both at gene expression and oxidative metabolism levels.

Authors: Kanarik, M; Alttoa, A; Matrov, D; Kõiv, K; Sharp, T

• Publication status: Published
• Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
• Volume: 21
• Issue: 1
• Pages: 92-107
• Publication date: 2011-01-01
• DOI: 10.1016/j.euroneuro.2010.06.015
• EISSN: 1873-7862
• ISSN: 0924-977X
• Language: English
• Keywords: Resilience, Psychological; Energy Metabolism; Gene Expression; Microarray Analysis; Dopamine Agonists; Depression; Behavior, Animal; Stress, Psychological; Body Weight; Rats, Wistar; Sucrose; Gene Expression Profiling; Animals; Rats; Apomorphine; Sweetening Agents; Adrenal Glands; Swimming; Brain