Cysteine, homocysteine and bone mineral density: a role for body composition?

Journal article

BACKGROUND: Plasma total cysteine (tCys) and homocysteine (tHcy) are associated with body composition, which in turn affects bone mineral density (BMD). OBJECTIVES: To investigate whether associations of tCys and tHcy with BMD are mediated through body composition (fat mass and/or lean mass). DESIGN: Using data from 5238 Hordaland Homocysteine Study participants, we fit multiple linear regression models and concentration-response curves to explore the relationships between tCys, tHcy, and BMD, with and without adjustment for body mass index (BMI), lean mass and/or fat mass. RESULTS: All associations were stronger in women. tCys was positively associated with BMD (women, partial r=0.11; men, partial r=0.07, p

Authors: Elshorbagy, A; Gjesdal, C; Nurk, E; Tell, G; Ueland, P

• Publication status: Published
• Journal: Bone
• Volume: 44
• Issue: 5
• Pages: 954-958
• Publication date: 2009-05-01
• DOI: 10.1016/j.bone.2008.12.018
• EISSN: 1873-2763
• ISSN: 8756-3282
• Language: English
• Keywords: Adult; Bone Density; Male; Body Mass Index; Linear Models; Aged; Cysteine; Homocysteine; Female; Humans; Body Composition