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Immune recruitment or suppression by glycan engineering of endogenous and therapeutic antibodies

Abstract:

Human serum IgG contains multiple glycoforms which exhibit a range of binding properties to effector molecules such as cellular Fc receptors. Emerging knowledge of how the Fc glycans contribute to the antibody structure and effector functions has opened new avenues for the exploitation of defined antibody glycoforms in the treatment of diseases. Here, we review the structure and activity of antibody glycoforms and highlight developments in antibody glycoengineering by both the manipulation of...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.bbagen.2016.04.016

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
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Funding agency for:
Bowden, TA
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Funding agency for:
Struwe, WB
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Funding agency for:
Crispin, MD
Publisher:
Elsevier Publisher's website
Journal:
BBA: General Subjects Journal website
Volume:
1860
Issue:
8
Pages:
1655–1668
Publication date:
2016
DOI:
EISSN:
1872-8006
ISSN:
0304-4165
URN:
uuid:0b2e8dd8-bff6-40c7-9e1b-14150b28494c
Source identifiers:
616204
Local pid:
pubs:616204

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