HIV evolution: CTL escape mutation and reversion after transmission.

Journal article

Within-patient HIV evolution reflects the strong selection pressure driving viral escape from cytotoxic T-lymphocyte (CTL) recognition. Whether this intrapatient accumulation of escape mutations translates into HIV evolution at the population level has not been evaluated. We studied over 300 patients drawn from the B- and C-clade epidemics, focusing on human leukocyte antigen (HLA) alleles HLA-B57 and HLA-B5801, which are associated with long-term HIV control and are therefore likely to exert...

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Authors: Leslie, A; Pfafferott, K; Chetty, P; Draenert, R; Addo, M

• Publication status: Published
• Journal: Nature medicine
• Volume: 10
• Issue: 3
• Pages: 282-289
• Publication date: 2004-03-01
• DOI: 10.1038/nm992
• EISSN: 1546-170X
• ISSN: 1078-8956
• Language: English
• Keywords: Amino Acid Sequence; HLA-B Antigens; Selection (Genetics); Epitopes; Genetic Variation; Child; Mutation; Humans; HIV-1; Phylogeny; Viral Load; Female; T-Lymphocytes, Cytotoxic; Evolution, Molecular; Likelihood Functions; HIV Infections; Infectious Disease Transmission, Vertical; Adult