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ZD6126: a novel vascular-targeting agent that causes selective destruction of tumor vasculature.

Abstract:

Physiological differences between tumor and normal vasculature provide a target for drug discovery. In particular, the immature nature of tumor vasculature may render it intrinsically sensitive to disruption by agents affecting the endothelial cell cytoskeleton, including tubulin-binding agents. In this article, we report the synthesis of a water-soluble phosphate prodrug, ZD6126, of the tubulin-binding agent N-acetylcolchinol. In vitro studies demonstrate the comparative tubulin-binding prop...

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Publication status:
Published

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Journal:
Cancer research More from this journal
Volume:
62
Issue:
24
Pages:
7247-7253
Publication date:
2002-12-01
EISSN:
1538-7445
ISSN:
0008-5472

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