ZD6126: a novel vascular-targeting agent that causes selective destruction of tumor vasculature.

Journal article

Physiological differences between tumor and normal vasculature provide a target for drug discovery. In particular, the immature nature of tumor vasculature may render it intrinsically sensitive to disruption by agents affecting the endothelial cell cytoskeleton, including tubulin-binding agents. In this article, we report the synthesis of a water-soluble phosphate prodrug, ZD6126, of the tubulin-binding agent N-acetylcolchinol. In vitro studies demonstrate the comparative tubulin-binding prop...

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Authors: Davis, P; Dougherty, G; Blakey, D; Galbraith, S; Tozer, G

• Publication status: Published
• Journal: Cancer research
• Volume: 62
• Issue: 24
• Pages: 7247-7253
• Publication date: 2002-12-01
• EISSN: 1538-7445
• ISSN: 0008-5472
• Language: English
• Keywords: Dose-Response Relationship, Drug; Cell Survival; Endothelium, Vascular; Mammary Neoplasms, Experimental; Necrosis; Tubulin; Pharyngeal Neoplasms; Xenograft Model Antitumor Assays; Angiogenesis Inhibitors; Mice; Female; Neoplasms, Experimental; Carcinoma, Squamous Cell; Humans; Cattle; Mice, Inbred CBA; Protein Binding; Colchicine; Animals; Organophosphorus Compounds; Neovascularization, Pathologic; Prodrugs; Mice, SCID; Adenocarcinoma