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Evaluating controlled human malaria infection in Kenyan adults with varying degrees of prior exposure to Plasmodium falciparum using sporozoites administered by intramuscular injection.

Abstract:

BACKGROUND: Controlled human malaria infection (CHMI) studies are a vital tool to accelerate vaccine and drug development. As CHMI trials are performed in a controlled environment, they allow unprecedented, detailed evaluation of parasite growth dynamics (PGD) and immunological responses. However, CHMI studies have not been routinely performed in malaria-endemic countries or used to investigate mechanisms of naturally-acquired immunity (NAI) to Plasmodium falciparum. METHODS: We conducted an ...

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Publication status:
Published

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Publisher copy:
10.3389/fmicb.2014.00686

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine
Role:
Author
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Journal:
Frontiers in microbiology
Volume:
5
Issue:
DEC
Pages:
686
Publication date:
2014-01-05
DOI:
EISSN:
1664-302X
ISSN:
1664-302X
URN:
uuid:0b166bad-1999-42d5-aa4b-f9744a597eb2
Source identifiers:
503243
Local pid:
pubs:503243
Language:
English
Keywords:

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