Evaluating controlled human malaria infection in Kenyan adults with varying degrees of prior exposure to Plasmodium falciparum using sporozoites administered by intramuscular injection.

Hodgson, SH; Juma, E; Salim, A; Magiri, C; Kimani, D; Njenga, D; Muia, A; Cole, AO; Ogwang, C; Awuondo, K; Lowe, B; Munene, M; Billingsley, PF; James, ER; Gunasekera, A; Sim, BK; Njuguna, P; Rampling, TW; Richman, A; Abebe, Y; Kamuyu, G; Muthui, M; Elias, SC; Molyneux, S; Gerry, S; Macharia, A; Williams, TN; Bull, PC; Hill, AV; Osier, FH; Draper, SJ; Bejon, P; Hoffman, SL; Ogutu, B; Marsh, K

Abstract:

BACKGROUND: Controlled human malaria infection (CHMI) studies are a vital tool to accelerate vaccine and drug development. As CHMI trials are performed in a controlled environment, they allow unprecedented, detailed evaluation of parasite growth dynamics (PGD) and immunological responses. However, CHMI studies have not been routinely performed in malaria-endemic countries or used to investigate mechanisms of naturally-acquired immunity (NAI) to Plasmodium falciparum. METHODS: We conducted an ...

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APA Style

Hodgson, S. H., Juma, E., Salim, A., Magiri, C., Kimani, D., Njenga, D., Muia, A., Cole, A. O., Ogwang, C., Awuondo, K., Lowe, B., Munene, M., Billingsley, P. F., James, E. R., Gunasekera, A., Sim, B. K., Njuguna, P., Rampling, T. W., Richman, A., … Marsh, K. (2014). Evaluating controlled human malaria infection in Kenyan adults with varying degrees of prior exposure to Plasmodium falciparum using sporozoites administered by intramuscular injection. Frontiers in Microbiology, 5(DEC), 686.

MLA Style

Hodgson, S. H., et al. “Evaluating Controlled Human Malaria Infection in Kenyan Adults with Varying Degrees of Prior Exposure to Plasmodium Falciparum Using Sporozoites Administered by Intramuscular Injection.” Frontiers in Microbiology, vol. 5, no. DEC, Frontiers in microbiology, 2014, p. 686.

Chicago Style

Hodgson, SH, E Juma, A Salim, C Magiri, D Kimani, D Njenga, A Muia, et al. 2014. “Evaluating Controlled Human Malaria Infection in Kenyan Adults with Varying Degrees of Prior Exposure to Plasmodium Falciparum Using Sporozoites Administered by Intramuscular Injection.” Frontiers in Microbiology 5 (DEC): 686.
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