Journal article
Evaluating controlled human malaria infection in Kenyan adults with varying degrees of prior exposure to Plasmodium falciparum using sporozoites administered by intramuscular injection.
- Abstract:
-
BACKGROUND: Controlled human malaria infection (CHMI) studies are a vital tool to accelerate vaccine and drug development. As CHMI trials are performed in a controlled environment, they allow unprecedented, detailed evaluation of parasite growth dynamics (PGD) and immunological responses. However, CHMI studies have not been routinely performed in malaria-endemic countries or used to investigate mechanisms of naturally-acquired immunity (NAI) to Plasmodium falciparum. METHODS: We conducted an ...
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- Publication status:
- Published
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- Publisher copy:
- 10.3389/fmicb.2014.00686
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Bibliographic Details
- Journal:
- Frontiers in microbiology
- Volume:
- 5
- Issue:
- DEC
- Pages:
- 686
- Publication date:
- 2014-01-01
- DOI:
- EISSN:
-
1664-302X
- ISSN:
-
1664-302X
- Source identifiers:
-
503243
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:503243
- UUID:
-
uuid:0b166bad-1999-42d5-aa4b-f9744a597eb2
- Local pid:
- pubs:503243
- Deposit date:
- 2015-01-23
Terms of use
- Copyright date:
- 2014
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