GATA3 is redundant for maintenance and self-renewal of hematopoietic stem cells.

Journal article

GATA3 has been identified as a master regulator of T helper cells, as well as being important for early thymic progenitors and T-cell commitment. However, Gata3 expression initiates already at the hematopoietic stem cell (HSC) level, implicating a potential role also in the regulation of HSCs. Herein we used a conditional Gata3 knockout strategy in which Gata3 expression was completely deleted from the earliest stage of embryonic hematopoietic development after emergence of HSCs from hemogeni...

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Authors: Buza-Vidas, N; Duarte, S; Luc, S; Bouriez-Jones, T; Woll, P

• Publication status: Published
• Journal: Blood
• Volume: 118
• Issue: 5
• Pages: 1291-1293
• Publication date: 2011-08-01
• DOI: 10.1182/blood-2011-02-338046
• EISSN: 1528-0020
• ISSN: 0006-4971
• Language: English
• Keywords: Signal Transduction; Mice; Hematopoietic Stem Cell Transplantation; Mice, Knockout; Animals; GATA3 Transcription Factor; Cells, Cultured; Hematopoiesis; Mice, Inbred C57BL; Hematopoietic Stem Cells; Cell Proliferation