BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes.

Journal article

A characteristic of the secondary response of CD8(+) T cells that distinguishes it from the primary response is the generation of greater numbers of effector cells. Because effector CD8(+) T cells are derived from a pool of less differentiated, replicating cells in secondary lymphoid organs, and because IL-2 mediates effector differentiation, the enhanced secondary response may reflect the enlargement of this generative pool by the transient repression of IL-2-mediated differentiation. We hav...

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Authors: Manders, P; Hunter, P; Telaranta, A; Carr, J; Marshall, J

• Publication status: Published
• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 102
• Issue: 21
• Pages: 7418-7425
• Publication date: 2005-05-01
• DOI: 10.1073/pnas.0501585102
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: H-Y Antigen; Female; Repressor Proteins; Interleukin-2; CD8-Positive T-Lymphocytes; Gene Targeting; Humans; Genetic Vectors; Interferon-gamma; Epitopes; Gene Components; Moloney murine leukemia virus; Immunologic Memory; Mice, Knockout; Silencer Elements, Transcriptional; DNA Primers; Animals; Cell Differentiation; Reverse Transcriptase Polymerase Chain Reaction; Vaccinia; Mice