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Nicotine inhibits firing activity of dorsal raphe 5-HT neurones in vivo.

Abstract:

It is established that the brain monoaminergic systems are among the main targets of several dependence-inducing drugs, including nicotine. In the present study extracellular electrophysiological recordings were performed to investigate the effects of nicotine on dorsal raphe 5-HT neurones. Nicotine, administered systemically (50-400 microg/kg, i.v.) in chloral hydrate-anaesthetised rats, induced a transient inhibition of the majority of 5-HT neurones recorded (38 of 45). The inhibition was r...

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Publication status:
Published

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Authors


Engberg, G More by this author
Erhardt, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Journal:
Naunyn-Schmiedeberg's archives of pharmacology
Volume:
362
Issue:
1
Pages:
41-45
Publication date:
2000-07-05
EISSN:
1432-1912
ISSN:
0028-1298
URN:
uuid:0b11c90c-0148-47b7-bef1-a6a612a6ca7c
Source identifiers:
185183
Local pid:
pubs:185183

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