Journal article icon

Journal article

Oral challenge with wild-type Salmonella Typhi induces distinct changes in B cell subsets in individuals who develop typhoid disease.

Abstract:

A novel human oral challenge model with wild-type Salmonella Typhi (S. Typhi) was recently established by the Oxford Vaccine Group. In this model, 104 CFU of Salmonella resulted in 65% of participants developing typhoid fever (referred here as typhoid diagnosis -TD-) 6-9 days post-challenge. TD was diagnosed in participants meeting clinical (oral temperature ≥38°C for ≥12h) and/or microbiological (S. Typhi bacteremia) endpoints. Changes in B cell subpopulations following S. Typhi challenge re...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pntd.0004766

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Blohmke, C
Grant:
Marie Curie Fellowship
More from this funder
Funding agency for:
Pollard, A
Grant:
092661
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Neglected Tropical Diseases Journal website
Volume:
10
Issue:
6
Pages:
e0004766
Publication date:
2016-06-14
Acceptance date:
2016-05-17
DOI:
EISSN:
1935-2735
ISSN:
1935-2727
Source identifiers:
628272
Language:
English
Pubs id:
pubs:628272
UUID:
uuid:0b0bd81d-5b80-4149-95b9-1036f766ad20
Local pid:
pubs:628272
Deposit date:
2016-06-17

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP