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Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells.

Abstract:

The naturally occurring population of dedicated regulatory T cells that coexpress CD4 and CD25 is known to play a key role in the maintenance of peripheral T-cell tolerance; however, their mechanism of action has remained obscure. Here we report that a member of the family of beta-galactoside-binding proteins, galectin-1, is overexpressed in regulatory T cells, and that expression is increased after activation. Most importantly, blockade of galectin-1 binding significantly reduced the inhibit...

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Publication status:
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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Blood More from this journal
Volume:
109
Issue:
5
Pages:
2058-2065
Publication date:
2007-03-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Language:
English
Keywords:
Pubs id:
pubs:229442
UUID:
uuid:0b08dfd4-8946-44b4-baba-4d8d580b0d75
Local pid:
pubs:229442
Source identifiers:
229442
Deposit date:
2013-11-16

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