Lipid raft domains and protein networks in T-cell receptor signal transduction.

Journal article

Activation of the T-cell antigen receptor (TCR) is a key event in triggering the physiological responses of T lymphocytes to antigen. The earliest TCR-evoked signalling steps, such as tyrosine phosphorylations, ras activation and induction of Ca(2+) fluxes, are initiated in the T-cell plasma membrane. It has been implicated that cholesterol- and sphingolipid-rich membrane domains, termed lipid rafts, form platforms for the regulation and transduction of TCR signals at the plasma membrane; however, recent experiments have now differentiated distinct roles for lipid-raft-mediated and protein-mediated interactions in the formation of TCR signalling membrane domains.

Authors: Harder, T

• Journal: Current opinion in immunology
• Volume: 16
• Issue: 3
• Pages: 353-359
• Publication date: 2004-06-01
• DOI: 10.1016/j.coi.2004.03.013
• EISSN: 1879-0372
• ISSN: 0952-7915
• Language: English
• Keywords: Membrane Lipids; Mice; T-Lymphocytes; Humans; Receptors, Antigen, T-Cell; Animals; Membrane Microdomains; Signal Transduction; Membrane Proteins