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Plasmacytoid dendritic cells prime IFN-gamma-secreting melanoma-specific CD8 lymphocytes and are found in primary melanoma lesions.

Abstract:

Plasmacytoid dendritic cells (PDC) are a small population of leukocytes specialized in the production of type I IFN. It has been shown that PDC have a potent T cell stimulatory capacity in allogeneic mixed lymphocyte reaction, However, their role in initiating primary immune responses remains elusive. We report that blood PDC efficiently prime naive CD8(+) lymphocytes specific for the melan-A(26-35) epitope to become IFN-gamma producing cells in vitro. In addition, we found that CD40L-stimula...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200323676

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Journal:
European journal of immunology More from this journal
Volume:
33
Issue:
4
Pages:
1052-1062
Publication date:
2003-04-01
DOI:
EISSN:
1521-4141
ISSN:
0014-2980

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