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Inhibition of NF-kappaB enhances the cytotoxicity of virus-directed enzyme prodrug therapy and oncolytic adenovirus cancer gene therapy.

Abstract:

Virus-directed enzyme prodrug therapy utilizing the bacterial enzyme nitroreductase delivered by a replication-defective adenovirus vector to activate the prodrug CB1954 is a promising strategy currently undergoing clinical trials in patients with a range of cancers. Similarly, selectively replicating oncolytic adenoviruses are entering clinical trials. An understanding of interactions between vector and target cell are critical to the development of these strategies. We demonstrate that aden...

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Publisher copy:
10.1038/sj.gt.3302510

Authors


Palmer, DH More by this author
Searle, PF More by this author
Journal:
Gene therapy
Volume:
12
Issue:
15
Pages:
1187-1197
Publication date:
2005-08-05
DOI:
EISSN:
1476-5462
ISSN:
0969-7128
URN:
uuid:0af97c6d-3aef-4b8d-906f-796e3af2274f
Source identifiers:
246410
Local pid:
pubs:246410

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