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Loss of fish actinotrichia proteins and the fin-to-limb transition.

Abstract:

The early development of teleost paired fins is strikingly similar to that of tetrapod limb buds and is controlled by similar mechanisms. One early morphological divergence between pectoral fins and limbs is in the fate of the apical ectodermal ridge (AER), the distal epidermis that rims the bud. Whereas the AER of tetrapods regresses after specification of the skeletal progenitors, the AER of teleost fishes forms a fold that elongates. Formation of the fin fold is accompanied by the synthesi...

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Publication status:
Published

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Publisher copy:
10.1038/nature09137

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Journal:
Nature
Volume:
466
Issue:
7303
Pages:
234-237
Publication date:
2010-07-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:0af2bcba-83f0-42e5-ad19-9071337d49be
Source identifiers:
237180
Local pid:
pubs:237180

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