Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases.

Journal article

The human MHC represents the strongest susceptibility locus for autoimmune diseases. However, the identification of the true predisposing gene(s) has been handicapped by the strong linkage disequilibrium across the region. Furthermore, most studies to date have been limited to the examination of a subset of the HLA and non-HLA genes with a marker density and sample size insufficient for mapping all independent association signals. We genotyped a panel of 1,472 SNPs to capture the common genom...

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Authors: Rioux, J; Goyette, P; Vyse, T; Hammarström, L; Fernando, M

• Publication status: Published
• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 106
• Issue: 44
• Pages: 18680-18685
• Publication date: 2009-11-01
• DOI: 10.1073/pnas.0909307106
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: Databases, Genetic; Genetic Predisposition to Disease; HLA Antigens; Polymorphism, Single Nucleotide; Humans; Immune System Diseases; International MHC and Autoimmunity Genetics Network; Chromosome Mapping; Genetic Testing; Major Histocompatibility Complex