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Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases.

Abstract:

The human MHC represents the strongest susceptibility locus for autoimmune diseases. However, the identification of the true predisposing gene(s) has been handicapped by the strong linkage disequilibrium across the region. Furthermore, most studies to date have been limited to the examination of a subset of the HLA and non-HLA genes with a marker density and sample size insufficient for mapping all independent association signals. We genotyped a panel of 1,472 SNPs to capture the common genom...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0909307106

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Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
106
Issue:
44
Pages:
18680-18685
Publication date:
2009-11-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:994
UUID:
uuid:0af248db-6616-4f5c-949a-d1f9d9d0480f
Local pid:
pubs:994
Source identifiers:
994
Deposit date:
2012-12-19

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