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Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor.

Abstract:

HIV's considerable capacity to vary its HLA-I-restricted peptide antigens allows it to escape from host cytotoxic T lymphocytes (CTLs). Nevertheless, therapeutics able to target HLA-I-associated antigens, with specificity for the spectrum of preferred CTL escape mutants, could prove effective. Here we use phage display to isolate and enhance a T-cell antigen receptor (TCR) originating from a CTL line derived from an infected person and specific for the immunodominant HLA-A(*)02-restricted, HI...

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Publication status:
Published

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Publisher copy:
10.1038/nm.1779

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Journal:
Nature medicine
Volume:
14
Issue:
12
Pages:
1390-1395
Publication date:
2008-12-05
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
URN:
uuid:0aeb051a-be2d-464d-a437-bcc3fd31bec1
Source identifiers:
163
Local pid:
pubs:163

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