Journal article
TBX2 controls a proproliferative gene expression program in melanoma
- Abstract:
-
Senescence shapes embryonic development, plays a key role in aging, and is a critical barrier to cancer initiation, yet how senescence is regulated remains incompletely understood. TBX2 is an antisenescence T-box family transcription repressor implicated in embryonic development and cancer. However, the repertoire of TBX2 target genes, its cooperating partners, and how TBX2 promotes proliferation and senescence bypass are poorly understood. Here, using melanoma as a model, we show that TBX2 l...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Cold Spring Harbor Laboratory Press Publisher's website
- Journal:
- Genes and Development Journal website
- Volume:
- 35
- Issue:
- 23-24
- Pages:
- 1657-1677
- Publication date:
- 2021-11-24
- Acceptance date:
- 2021-10-22
- DOI:
- EISSN:
-
1549-5477
- ISSN:
-
0890-9369
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1205815
- Local pid:
- pubs:1205815
- Deposit date:
- 2021-10-26
Terms of use
- Copyright holder:
- Lu et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 Lu et al. This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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