- Abstract:
-
The merozoite surface protein-1 (MSP1) is the most studied malaria blood-stage vaccine candidate. Lymphokines such as interferon gamma (IFN-gamma) and interleukin 4 (IL-4) may mediate blood-stage specific protection. Here we identify Plasmodiumfalciparum MSP1 T-cell epitopes capable of rapid induction of IFN-gamma and/or IL-4 from peripheral blood mononuclear cells of East and West African donors. Both allelic forms of these novel MSP1 T-cell epitopes were stimulatory. An unusually high numbe...
Expand abstract - Publication status:
- Published
- Journal:
- The American journal of tropical medicine and hygiene
- Volume:
- 64
- Issue:
- 3-4
- Pages:
- 194-203
- Publication date:
- 2001
- EISSN:
-
1476-1645
- ISSN:
-
0002-9637
- URN:
-
uuid:0adeb6c0-aab9-4559-a19d-77258cb5ee2e
- Source identifiers:
-
31913
- Local pid:
- pubs:31913
- Language:
- English
- Keywords:
- Copyright date:
- 2001
Journal article
Identification of frequently recognized dimorphic T-cell epitopes in plasmodium falciparum merozoite surface protein-1 in West and East Africans: lack of correlation of immune recognition and allelic prevalence.
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