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Identification of frequently recognized dimorphic T-cell epitopes in plasmodium falciparum merozoite surface protein-1 in West and East Africans: lack of correlation of immune recognition and allelic prevalence.

Abstract:

The merozoite surface protein-1 (MSP1) is the most studied malaria blood-stage vaccine candidate. Lymphokines such as interferon gamma (IFN-gamma) and interleukin 4 (IL-4) may mediate blood-stage specific protection. Here we identify Plasmodiumfalciparum MSP1 T-cell epitopes capable of rapid induction of IFN-gamma and/or IL-4 from peripheral blood mononuclear cells of East and West African donors. Both allelic forms of these novel MSP1 T-cell epitopes were stimulatory. An unusually high numbe...

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Publication status:
Published

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Authors


Flanagan, KL More by this author
Odhiambo, K More by this author
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Journal:
The American journal of tropical medicine and hygiene
Volume:
64
Issue:
3-4
Pages:
194-203
Publication date:
2001
EISSN:
1476-1645
ISSN:
0002-9637
URN:
uuid:0adeb6c0-aab9-4559-a19d-77258cb5ee2e
Source identifiers:
31913
Local pid:
pubs:31913

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