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Molecular mechanism of endothelial nitric-oxide synthase activation by Platycodon grandiflorum root-derived saponins.

Abstract:

Nitric oxide (NO) produced by endothelial nitric-oxide synthase (eNOS) has antithrombotic and antiatherosclerotic properties in the vasculature. Previously, we demonstrated that saponins derived from the roots of Platycodon grandiflorum (CKS) inhibited the tumor necrosis factor-alpha-induced expression of adhesion molecules in human endothelial cells. In this study, we found that CKS increased eNOS phosphorylation and NO production in human endothelial cells. Treatment with CKS increased the ...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Journal:
Toxicology letters
Volume:
195
Issue:
2-3
Pages:
106-113
Publication date:
2010-06-05
DOI:
EISSN:
1879-3169
ISSN:
0378-4274
URN:
uuid:0addc602-3911-40ee-8341-d47b9bd7723e
Source identifiers:
272993
Local pid:
pubs:272993

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