- Abstract:
-
Leukocyte activity is controlled by numerous interactions between membrane receptors and ligands on the cell surface. These interactions are of low affinity making detection difficult. We developed a sensitive assay that could readily detect extremely weak interactions such as that between CD200 and the activating receptor CD200RLa (K(d)>500 microM) at the protein level. We used the new technology to screen for interactions of inhibitory receptors for collagens. We confirmed that both huma...
Expand abstract - Publisher copy:
- 10.1002/eji.200839188
-
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- Journal:
- European journal of immunology
- Volume:
- 39
- Issue:
- 4
- Pages:
- 1167-1175
- Publication date:
- 2009-04-05
- DOI:
- EISSN:
-
1521-4141
- ISSN:
-
0014-2980
- URN:
-
uuid:0adbbe38-c227-4267-aec4-d418d92f9d32
- Source identifiers:
-
223847
- Local pid:
- pubs:223847
- Copyright date:
- 2009
Journal article
New assay to detect low-affinity interactions and characterization of leukocyte receptors for collagen including leukocyte-associated Ig-like receptor-1 (LAIR-1).
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