- Abstract:
-
Budding yeast Slx4 interacts with the structure-specific endonuclease Slx1 to ensure completion of ribosomal DNA replication. Slx4 also interacts with the Rad1-Rad10 endonuclease to control cleavage of 3' flaps during repair of double-strand breaks (DSBs). Here we describe the identification of human SLX4, a scaffold for DNA repair nucleases XPF-ERCC1, MUS81-EME1, and SLX1. SLX4 immunoprecipitates show SLX1-dependent nuclease activity toward Holliday junctions and MUS81-dependent activity tow...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.molcel.2009.06.020
-
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- Journal:
- Molecular cell
- Volume:
- 35
- Issue:
- 1
- Pages:
- 116-127
- Publication date:
- 2009-07-05
- DOI:
- EISSN:
-
1097-4164
- ISSN:
-
1097-2765
- URN:
-
uuid:0ad36285-a960-4980-991c-91bff670fdd7
- Source identifiers:
-
237047
- Local pid:
- pubs:237047
- Copyright date:
- 2009
Journal article
Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair.
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