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Journal article

Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair.

Abstract:

Budding yeast Slx4 interacts with the structure-specific endonuclease Slx1 to ensure completion of ribosomal DNA replication. Slx4 also interacts with the Rad1-Rad10 endonuclease to control cleavage of 3' flaps during repair of double-strand breaks (DSBs). Here we describe the identification of human SLX4, a scaffold for DNA repair nucleases XPF-ERCC1, MUS81-EME1, and SLX1. SLX4 immunoprecipitates show SLX1-dependent nuclease activity toward Holliday junctions and MUS81-dependent activity tow...

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Publication status:
Published

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Journal:
Molecular cell
Volume:
35
Issue:
1
Pages:
116-127
Publication date:
2009-07-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:0ad36285-a960-4980-991c-91bff670fdd7
Source identifiers:
237047
Local pid:
pubs:237047

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