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Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: a study of 20 cases.

Abstract:

This study identifies multiple copies of the AML1 gene on a duplicated chromosome 21, dup(21), as a recurrent abnormality in acute lymphoblastic leukemia (ALL). Clusters of AML1 signals were visible at interphase by fluorescence in situ hybridization (FISH). In metaphase, they appeared tandemly duplicated on marker chromosomes of five distinct morphological types: large or small acrocentrics, metacentrics, submetacentrics or rings. The markers comprised only chromosome 21 material. Karyotypes...

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Publication status:
Published

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Publisher copy:
10.1038/sj.leu.2402849

Authors


Harewood, L More by this author
Robinson, H More by this author
Al-Obaidi, MJ More by this author
Jalali, GR More by this author
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Journal:
Leukemia
Volume:
17
Issue:
3
Pages:
547-553
Publication date:
2003-03-05
DOI:
EISSN:
1476-5551
ISSN:
0887-6924
URN:
uuid:0abfbd2c-0253-430d-ad0a-5a08c810e752
Source identifiers:
38561
Local pid:
pubs:38561

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