Journal article
Abolition of zolpidem sensitivity in mice with a point mutation in the GABAA receptor gamma2 subunit.
- Abstract:
-
Agonists of the allosteric benzodiazepine site of GABAA receptors bind at the interface of the alpha and gamma subunits. Here, we tested the in vivo contribution of the gamma2 subunit to the actions of zolpidem, an alpha1 subunit selective benzodiazepine agonist, by generating mice with a phenylalanine (F) to isoleucine (I) substitution at position 77 in the gamma2 subunit. The gamma2F77I mutation has no major effect on the expression of GABAA receptor subunits in the cerebellum. The potency ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.neuropharm.2004.03.007
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Bibliographic Details
- Journal:
- Neuropharmacology
- Volume:
- 47
- Issue:
- 1
- Pages:
- 17-34
- Publication date:
- 2004-07-01
- DOI:
- EISSN:
-
1873-7064
- ISSN:
-
0028-3908
- Source identifiers:
-
329223
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:329223
- UUID:
-
uuid:0abe6f19-3e67-443f-a4f3-381cd64bee10
- Local pid:
- pubs:329223
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2004
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