- Abstract:
-
Evidence suggests that nerve growth factor (NGF) may function as a mediator of some persistent pain states. We have used a synthetic protein, trkA-IgG, to sequester endogenous NGF and block the survival effects of NGF on cultured sensory neurons. We show that administration of trkA-IgG produces a sustained thermal and chemical hypoalgesia and leads to a downregulation of the sensory neuropeptide CGRP (calcitonin gene-related peptide) in treated sensory neurons. Acute administration of the mol...
Expand abstract - Publisher copy:
- 10.1038/nm0895-774
-
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- Journal:
- Nature medicine
- Volume:
- 1
- Issue:
- 8
- Pages:
- 774-780
- Publication date:
- 1995-08-05
- DOI:
- EISSN:
-
1546-170X
- ISSN:
-
1078-8956
- URN:
-
uuid:0abbc424-af2f-44aa-90b5-d89b8ff87fce
- Source identifiers:
-
365820
- Local pid:
- pubs:365820
- Language:
- English
- Keywords:
- Copyright date:
- 1995
Journal article
The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule.
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