Journal article icon

Journal article

The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule.

Abstract:

Evidence suggests that nerve growth factor (NGF) may function as a mediator of some persistent pain states. We have used a synthetic protein, trkA-IgG, to sequester endogenous NGF and block the survival effects of NGF on cultured sensory neurons. We show that administration of trkA-IgG produces a sustained thermal and chemical hypoalgesia and leads to a downregulation of the sensory neuropeptide CGRP (calcitonin gene-related peptide) in treated sensory neurons. Acute administration of the mol...

Expand abstract

Actions


Access Document


Publisher copy:
10.1038/nm0895-774

Authors


Journal:
Nature medicine
Volume:
1
Issue:
8
Pages:
774-780
Publication date:
1995-08-05
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
URN:
uuid:0abbc424-af2f-44aa-90b5-d89b8ff87fce
Source identifiers:
365820
Local pid:
pubs:365820

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP