Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients.

Journal article

Epigenetic dysregulation of gene expression is thought to be critically involved in the pathophysiology of Alzheimer's disease (AD). Recent studies indicate that DNA methylation and DNA hydroxymethylation are 2 important epigenetic mechanisms that regulate gene expression in the aging brain. However, very little is known about the levels of markers of DNA methylation and hydroxymethylation in the brains of patients with AD, the cell-type specificity of putative AD-related alterations in these...

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Authors: Chouliaras, L; Mastroeni, D; Delvaux, E; Grover, A; Kenis, G

• Journal: Neurobiology of aging
• Volume: 34
• Issue: 9
• Pages: 2091-2099
• Publication date: 2013-09-01
• DOI: 10.1016/j.neurobiolaging.2013.02.021
• EISSN: 1558-1497
• ISSN: 0197-4580
• Language: English
• Keywords: Cytidine; DNA Methylation; Aged; Humans; Male; Female; Deoxycytidine; Hydroxylation; Hippocampus; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Aging; Aged, 80 and over; Alzheimer Disease