Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight.

Journal article

To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEKR1 and CCNL1 (P = 2 x 10(-35)) and rs9883204 in ADCY5 (P = 7 x 10(-15)) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and susceptibility to type 2 diabetes, ...

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Authors: Freathy, R; Mook-Kanamori, DO; Sovio, U; Prokopenko, I; Timpson, N

• Publication status: Published
• Journal: Nature genetics
• Volume: 42
• Issue: 5
• Pages: 430-435
• Publication date: 2010-05-01
• DOI: 10.1038/ng.567
• EISSN: 1546-1718
• ISSN: 1061-4036
• Language: English
• Keywords: Glucose; Female; Cyclins; Genetic Investigation of ANthropometric Traits (GIANT) Consortium; Wellcome Trust Case Control Consortium; Early Growth Genetics (EGG) Consortium; Pregnancy; Ethnic Groups; Alleles; Models, Genetic; Isoenzymes; Adenylate Cyclase; Humans; Genetic Predisposition to Disease; Cohort Studies; Birth Weight; Genotype; Meta-Analyses of Glucose and Insulin-related traits Consortium; Diabetes Mellitus, Type 2; Male