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Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight.

Abstract:

To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEKR1 and CCNL1 (P = 2 x 10(-35)) and rs9883204 in ADCY5 (P = 7 x 10(-15)) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and susceptibility to type 2 diabetes, ...

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Publication status:
Published

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Publisher copy:
10.1038/ng.567

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Journal:
Nature genetics More from this journal
Volume:
42
Issue:
5
Pages:
430-435
Publication date:
2010-05-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036

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