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Phosphorylation of BRN2 modulates its interaction with the Pax3 promoter to control melanocyte migration and proliferation.

Abstract:

MITF-M and PAX3 are proteins central to the establishment and transformation of the melanocyte lineage. They control various cellular mechanisms, including migration and proliferation. BRN2 is a POU domain transcription factor expressed in melanoma cell lines and is involved in proliferation and invasion, at least in part by regulating the expression of MITF-M and PAX3. The T361 and S362 residues of BRN2, both in the POU domain, are conserved throughout the POU protein family and are targets ...

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Publication status:
Published

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Publisher copy:
10.1128/mcb.06257-11

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Journal:
Molecular and cellular biology More from this journal
Volume:
32
Issue:
7
Pages:
1237-1247
Publication date:
2012-04-01
DOI:
EISSN:
1098-5549
ISSN:
0270-7306

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