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Spatiotemporal mathematical modelling of mutations of the dhps gene in African Plasmodium falciparum.

Abstract:

BACKGROUND: Plasmodium falciparum has repeatedly evolved resistance to first-line anti-malarial drugs, thwarting efforts to control and eliminate the disease and in some period of time this contributed largely to an increase in mortality. Here a mathematical model was developed to map the spatiotemporal trends in the distribution of mutations in the P. falciparum dihydropteroate synthetase (dhps) gene that confer resistance to the anti-malarial sulphadoxine, and are a useful marker for the co...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/1475-2875-12-249

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Publisher:
BioMed Central Publisher's website
Journal:
Malar J Journal website
Volume:
12
Issue:
1
Article number:
249
Publication date:
2013-01-01
DOI:
EISSN:
1475-2875
ISSN:
1475-2875
Source identifiers:
414515

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