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Marked downregulation of the granulopoiesis regulator LEF1 is associated with disease progression in the myelodysplastic syndromes.

Abstract:

Lymphoid enhancer-binding factor 1 (LEF1) is a neutrophilic granulopoiesis regulator whose absence is critical in congenital neutropenia. We have shown LEF1 downregulation in the CD34(+) cells of the majority of myelodysplastic syndromes (MDS) patients. LEF1 was the most significant differentially expressed gene between early and advanced MDS. Marked LEF1 downregulation was found in 27/32 patients with advanced MDS and in 6/35 patients with early MDS, and was associated with neutropenia. Down...

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Publication status:
Published

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Journal:
British journal of haematology
Volume:
146
Issue:
1
Pages:
86-90
Publication date:
2009-06-05
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
URN:
uuid:0aae50f2-9e19-4f08-b658-dc4caf813c6d
Source identifiers:
246242
Local pid:
pubs:246242

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