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Chromosomal gene movements reflect the recent origin and biology of therian sex chromosomes

Abstract:

Mammalian sex chromosomes stem from ancestral autosomes and have substantially differentiated. It was shown that X-linked genes have generated duplicate intronless gene copies (retrogenes) on autosomes due to this differentiation. However, the precise driving forces for this out-of-X gene “movement” and its evolutionary onset are not known. Based on expression analyses of male germ-cell populations, we here substantiate and extend the hypothesis that autosomal retrogenes functionally compensa...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pbio.0060080

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Biology Journal website
Volume:
6
Issue:
4
Pages:
ARTN e80
Publication date:
2008-04-01
Acceptance date:
2008-02-14
DOI:
EISSN:
1545-7885
ISSN:
1544-9173
Language:
English
Keywords:
UUID:
uuid:0aacb52c-0737-4d91-830c-0b4879dd0abf
Local pid:
pubs:345405
Source identifiers:
345405
Deposit date:
2013-11-16

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