Type 2 diabetic mice have increased arteriolar tone and blood pressure: enhanced release of COX-2-derived constrictor prostaglandins.

Journal article

OBJECTIVE: Type 2 diabetes mellitus (T2-DM) is frequently associated with vascular dysfunction and elevated blood pressure, yet the underlying mechanisms are not completely understood. We hypothesized that in T2-DM, the regulation of peripheral vascular resistance is altered because of changes in local vasomotor mechanisms. METHODS AND RESULTS: In mice with T2-DM (C57BL/KsJ-(db-)/db-), systolic and mean arterial pressures measured by the tail cuff method were significantly elevated compared ...

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Authors: Bagi, Z; Erdei, N; Toth, A; Li, W; Hintze, T

• Publication status: Published
• Journal: Arteriosclerosis, thrombosis, and vascular biology
• Volume: 25
• Issue: 8
• Pages: 1610-1616
• Publication date: 2005-08-01
• DOI: 10.1161/01.atv.0000172688.26838.9f
• EISSN: 1524-4636
• ISSN: 1079-5642
• Language: English
• Keywords: Arterioles; Blood Pressure; Vascular Resistance; Mice, Mutant Strains; Mice, Inbred C57BL; Muscle, Skeletal; Aorta; Vasoconstriction; Arachidonic Acid; Cyclooxygenase 2; Diabetic Angiopathies; Male; Diabetes Mellitus, Type 2; Cyclooxygenase 1; Prostaglandins; Mice; Animals