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Journal article

Type 2 diabetic mice have increased arteriolar tone and blood pressure: enhanced release of COX-2-derived constrictor prostaglandins.

Abstract:

OBJECTIVE: Type 2 diabetes mellitus (T2-DM) is frequently associated with vascular dysfunction and elevated blood pressure, yet the underlying mechanisms are not completely understood. We hypothesized that in T2-DM, the regulation of peripheral vascular resistance is altered because of changes in local vasomotor mechanisms. METHODS AND RESULTS: In mice with T2-DM (C57BL/KsJ-(db-)/db-), systolic and mean arterial pressures measured by the tail cuff method were significantly elevated compared ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
Arteriosclerosis, thrombosis, and vascular biology More from this journal
Volume:
25
Issue:
8
Pages:
1610-1616
Publication date:
2005-08-01
DOI:
EISSN:
1524-4636
ISSN:
1079-5642
Language:
English
Keywords:
Pubs id:
pubs:164422
UUID:
uuid:0aa3606e-d31d-4c0b-a213-86795c546c97
Local pid:
pubs:164422
Source identifiers:
164422
Deposit date:
2012-12-19

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