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Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling.

Abstract:

Heart failure remains a leading cause of morbidity and mortality worldwide. Although depressed pump function is common, development of effective therapies to stimulate contraction has proven difficult. This is thought to be attributable to their frequent reliance on cAMP stimulation to increase activator Ca(2+). A potential alternative is nitroxyl (HNO), the 1-electron reduction product of nitric oxide (NO) that improves contraction and relaxation in normal and failing hearts in vivo. The mec...

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Authors


Tocchetti, CG More by this author
Froehlich, JP More by this author
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Journal:
Circulation research
Volume:
100
Issue:
1
Pages:
96-104
Publication date:
2007-01-05
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
URN:
uuid:0a9d34ad-e9a8-4fbc-965a-efe2e6789d60
Source identifiers:
237727
Local pid:
pubs:237727

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