Journal article icon

Journal article

High hyperdiploidy among adolescents and adults with acute lymphoblastic leukaemia (ALL): cytogenetic features, clinical characteristics and outcome.

Abstract:

High hyperdiploidy (HeH, 51-65 chromosomes) is an established genetic subtype of acute lymphoblastic leukaemia (ALL). The clinical and cytogenetic features as well as outcome of HeH among adolescents and adults have not been thoroughly investigated. Among 1232 B-cell precursor ALL patients (15-65 years) treated in the UKALLXII/ECOG2993 trial, 160 (13%) had a HeH karyotype, including 80 patients aged >24 years. The frequency of HeH was the same in Philadelphia chromosome (Ph)-positive and -...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1038/leu.2013.379

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
Expand authors...
Publisher:
Nature Publishing Group Publisher's website
Journal:
Leukemia Journal website
Volume:
28
Issue:
7
Pages:
1511-1518
Publication date:
2014-01-01
DOI:
EISSN:
1476-5551
ISSN:
0887-6924
Source identifiers:
444349
Language:
English
Keywords:
Pubs id:
pubs:444349
UUID:
uuid:0a925ce5-14b5-45d5-9148-38ca27944f06
Local pid:
pubs:444349
Deposit date:
2014-02-08

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP