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Mature dendritic cells differentiated in the presence of interferon-beta and interleukin-3 prime functional antigen-specific CD8 T cells.

Abstract:

Dendritic cell (DC)-based immunization represents a promising approach for the immunotherapy of cancer. The optimal conditions required to prepare DCs remain to be defined. Monocytes incubated in the presence of interferon (IFN)-beta and interleukin (IL)-3 give rise to a distinct type of DCs (IFN-beta/IL-3 DCs) that are particularly efficient at eliciting IFN-gamma and IL-5 production by allogeneic helper T cells. We assessed the capacity of this new type of DCs to prime antigen-specific naiv...

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Publication status:
Published

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Authors


Renneson, J More by this author
Goldman, M More by this author
Marchant, A More by this author
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Journal:
Clinical and experimental immunology
Volume:
139
Issue:
3
Pages:
468-475
Publication date:
2005-03-05
DOI:
EISSN:
1365-2249
ISSN:
0009-9104
URN:
uuid:0a8c4d70-b7d1-4528-b47c-0b902f345262
Source identifiers:
33013
Local pid:
pubs:33013

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