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Allatostatin A signalling in Drosophila regulates feeding and sleep and is modulated by PDF

Abstract:

Feeding and sleep are fundamental behaviours with significant interconnections and cross-modulations. The circadian system and peptidergic signals are important components of this modulation, but still little is known about the mechanisms and networks by which they interact to regulate feeding and sleep. We show that specific thermogenetic activation of peptidergic Allatostatin A (AstA)-expressing PLP neurons and enteroendocrine cells reduces feeding and promotes sleep in the fruit fly Drosop...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pgen.1006346

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Name:
Deutsche Forschungsgemeinschaft
Grant:
WE 2652/4-2
“Insect timing” project B2
FO 207/14-1
Publisher:
Public Library of Science
Journal:
PLoS Genetics More from this journal
Volume:
12
Issue:
9
Article number:
e1006346
Publication date:
2016-09-30
Acceptance date:
2016-09-07
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Pmid:
27689358
Language:
English
Keywords:
Pubs id:
pubs:648598
UUID:
uuid:0a849348-c624-43e5-9855-2310c1d1370d
Local pid:
pubs:648598
Source identifiers:
648598
Deposit date:
2016-11-29

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