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An in vivo and in vitro H-magnetic resonance spectroscopy study of mdx mouse brain: abnormal development or neural necrosis?

Abstract:

Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder primarily affecting young boys, often causing mental retardation in addition to the well-known progressive muscular weakness. Normal dystrophin expression is lacking in skeletal muscle and the central nervous system (CNS) of both DMD children and the mdx mouse model. The underlying biochemical lesion causing mental impairment in DMD is unknown. 1H-magnetic resonance spectroscopy (1H-MRS) detects choline-containing compounds, cr...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Parkes, HG More by this author
Journal:
Journal of the neurological sciences
Volume:
141
Issue:
1-2
Pages:
13-18
Publication date:
1996-09-05
DOI:
EISSN:
1878-5883
ISSN:
0022-510X
URN:
uuid:0a83dfde-143c-41e7-8f71-75df78b82866
Source identifiers:
376237
Local pid:
pubs:376237

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