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An in vivo and in vitro H-magnetic resonance spectroscopy study of mdx mouse brain: abnormal development or neural necrosis?

Abstract:

Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder primarily affecting young boys, often causing mental retardation in addition to the well-known progressive muscular weakness. Normal dystrophin expression is lacking in skeletal muscle and the central nervous system (CNS) of both DMD children and the mdx mouse model. The underlying biochemical lesion causing mental impairment in DMD is unknown. 1H-magnetic resonance spectroscopy (1H-MRS) detects choline-containing compounds, cr...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Journal of the neurological sciences
Volume:
141
Issue:
1-2
Pages:
13-18
Publication date:
1996-09-01
DOI:
EISSN:
1878-5883
ISSN:
0022-510X
Source identifiers:
376237
Language:
English
Keywords:
Pubs id:
pubs:376237
UUID:
uuid:0a83dfde-143c-41e7-8f71-75df78b82866
Local pid:
pubs:376237
Deposit date:
2013-11-16

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