Thesis
Investigating the regulation of ACC1 activity in pancreatic beta cells
- Abstract:
-
Aims:
Acetyl-coA Carboxylase 1 (ACC1) is an enzyme that couples glucose metabolism with de novo lipid synthesis in lipogenic tissues, by converting acetyl-CoA to malonyl-CoA. In beta cells, ACC1 plays a critical role in beta cell growth and insulin secretion . However, very little is known about how ACC1 activity is regulated in beta cells. The aims of the current project were to 1) assess the role of the AMP-activated protein kinase phospho-site serine 79 (ACC1S79) in beta ...
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Authors
Contributors
+ Cantley, J
- Division:
- MSD
- Department:
- Physiology Anatomy & Genetics
- Sub department:
- Physiology Anatomy & Genetics
- Role:
- Supervisor
+ Christian, H
- Division:
- MSD
- Department:
- Physiology Anatomy & Genetics
- Sub department:
- Physiology Anatomy & Genetics
- Role:
- Supervisor
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Deposit date:
-
2021-03-31
Terms of use
- Copyright holder:
- Bany Bakar, R
- Copyright date:
- 2020
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