- Abstract:
-
Individuals with the rare developmental disorder fibrodysplasia ossificans progressiva (FOP) experience disabling heterotopic ossification caused by a gain of function mutation in the intracellular region of the BMP type I receptor kinase ALK2, encoded by the gene ACVR1. Small molecule BMP type I receptor inhibitors that block this ossification in FOP mouse models have been derived from the pyrazolo[1,5-a]pyrimidine scaffold of dorsomorphin. While the first derivative LDN-193189 exhibited pan...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.0MB)
-
- Publisher copy:
- 10.1016/j.bone.2017.09.004
-
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- Publisher:
- Elsevier Publisher's website
- Journal:
- Bone Journal website
- Volume:
- 109
- Pages:
- 251-258
- Publication date:
- 2017-09-12
- Acceptance date:
- 2017-09-11
- DOI:
- EISSN:
-
1873-2763
- ISSN:
-
8756-3282
- Pubs id:
-
pubs:730169
- URN:
-
uri:0a77cc92-4c73-45e9-a2bf-68f21ff8285b
- UUID:
-
uuid:0a77cc92-4c73-45e9-a2bf-68f21ff8285b
- Local pid:
- pubs:730169
- Language:
- English
- Keywords:
- Copyright holder:
- © 2017 Williams and Bullock. Published by Elsevier Inc
- Copyright date:
- 2017
- Notes:
-
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
For the full funder list, see the article
Journal article
Structural basis for the potent and selective binding of LDN-212854 to the BMP receptor kinase ALK2
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